Dipeptides

L-a-dipeptides (dipeptides) laguma baranin ku dhawaad ​​waxay leeyihiin borotiinno iyo amino acids.Cilmi-baarista aasaasiga ah ayaa lagu sameeyay L-aspartyl-L-phenylalanine methylester (aspartame) iyo Ala-Gln (Lalanyl-L-glutamine) sababtoo ah waxaa loo isticmaalaa alaabada ganacsiga caanka ah.Marka laga soo tago xaqiiqdan, sabab kale oo badan oo dipeptides ah oo aan si fiican loo baarin ayaa ah sababtoo ah wax soo saarka dipeptide ayaa ka maqan habab wax soo saar oo wax ku ool ah, inkastoo dhowr kiimiko iyo hababka chemoenzymatic la soo sheegay.

Carnosine - tusaale ahaan dipeptide
Ilaa dhawaan, habab cusub ayaa loo sameeyay isku-dhafka dipeptide kaas oo dipeptides lagu soo saaro hababka halsano.Qaar ka mid ah dipeptides waxay leeyihiin awoodo jireed oo gaar ah, taasoo u oggolaanaysa inay suurtogal tahay inay dedejiyaan codsiyada dipeptide ee qaybaha kala duwan ee cilmi-baarista sayniska.L-a-dipeptides waxay ka kooban yihiin isku-xidhka peptide-ka ee aan dhibsanayn ee laba amino acids, haddana diyaar uma aha ugu horreyntii sababta oo ah habka wax-soo-saarka ee waxtarka leh.Dipeptides, si kastaba ha ahaatee, waxay leeyihiin shaqooyin aad u xiiso badan, iyo macluumaadka sayniska ee ku hareeraysan iyaga ayaa sii kordhaya.Tani waxay ka tagtaa cilmi-baarayaal badan oo leh mas'uuliyadda horumarinta hababka waxtarka leh ee waxtarka leh ee wax soo saarka dipeptide.Marka goobtan si buuxda loo barto, waxaa la filayaa inaan wax badan ka baran karno sida dhabta ah ee peptides ay yihiin.

Dipeptides waxay leeyihiin laba hawlood oo aasaasi ah, kuwaas oo:
1. Asiidhyada amino-ka soo saara
2. Dipeptide laftiisa

Sida laga soosaaray asiidhyada amino, dipeptides, oo ay weheliso asiidhkooda amino waxa ku jira sifooyin kimikaad oo kala duwan, laakiin inta badan waxay wadaagaan saameyn jidheed isku mid ah.Tani waa sababta oo ah dipeptides waxay hoos u dhigeen asiidhyada amino ee kala duwan ee noolaha, kuwaas oo leh astaamo jireed oo kala duwan.Tusaale ahaan, L-glutamine (Gln) waa kuleyl-labile, halka Ala-Gin (L-alanyl-L-glutamine) uu u dulqaadan karo kulaylka.

Isku-dubarid kiimikaad ee dipeptides waxay u dhacdaa sida soo socota:
1. Dhammaan kooxaha dipeptide functional waa la ilaaliyaa (marka laga reebo kuwa ku lug leh abuurista bond peptide ee amino acids).
2. Amino acid-ka la ilaaliyo ee kooxda karboxyl ee bilaashka ah waa la hawlgeliyay.
3. Amino acid-ka firfircoon waxa uu la falgalaa amino acid-ka kale ee la ilaaliyo.
4. Kooxaha difaaca ee ku jira dipeptide waa la saarayaa.